Article
Identification of p53 gene mutations in gastrointestinal and pancreatic carcinoids by nonradioisotopic SSCA.
Virchows Archiv. B, Cell pathology including molecular pathology - 1 Jan 1993
Lohmann D R, Funk A, Niedermeyer H P, Häupel S, Höfler H
Abstract excerpt
A nonisotopic screening method based on single-strand DNA conformation analysis (SSCA) was established for the identification of p53 gene alterations in achieved tissue samples. The sensitivity of this approach was validated by testing mutations previously identified by direct sequencing. Applyin...
Topics
- Base Sequence
- Carcinoid Tumor
- DNA, Neoplasm
- Deoxyribonucleases, Type II Site-Specific
- Gastrointestinal Neoplasms
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Pancreatic Neoplasms