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Article

Detection of DNA aberrations in human cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products.

The Tohoku journal of experimental medicine - 1 Oct 1992

Murakami Y, Suzuki Y, Kishimoto Y, Hirohashi S, Hayashi K, Sekiya T

Abstract excerpt

We have developed a simple, sensitive method, single-strand conformation polymorphism (SSCP) analysis, to detect a single nucleotide substitution in a DNA fragment amplified and labeled by the polymerase chain reaction (PCR). Mobility shift of single-stranded DNAs due to their specific conformations on non-denaturing polyacrylamide gel electrophoresis can reveal DNA aberrations. By the PCR-SSCP analysis of DNAs...

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Identifiers

PMID: 1339101
DOI: 10.1620/tjem.168.247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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