Article
Evaluation of p53 mutation in pancreatic acinar cell carcinomas of humans and transgenic mice.
Pancreas - 1 Jan 1998
Terhune P G, Memoli V A, Longnecker D S
Abstract excerpt
Mutation of the p53 tumor suppressor gene is found in a large number of exocrine pancreatic tumors. The majority of these tumors is of the ductal cell phenotype. We examined 12 human acinar cell carcinomas and 42 transgenic mouse carcinomas (including 36 acinar cell tumors, four islet cell tumors, and two liver metastases of primary acinar cell tumors) for evidence of p53 mutation. Immunohistochemistry was used...
Topics
- Animals
- Antibodies, Monoclonal
- Carcinoma, Acinar Cell
- DNA, Neoplasm
- Genes, p53
- Humans
- Immunoenzyme Techniques
- Mice
- Mice, Transgenic
- Mutation
- Nucleic Acid Heteroduplexes
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Tumor Suppressor Protein p53