Mutants in dolichol synthesis: conversion of polyprenol to dolichol appears to be a rate-limiting step in dolichol synthesis.

doi:10.1093/glycob/3.5.481

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Article

Mutants in dolichol synthesis: conversion of polyprenol to dolichol appears to be a rate-limiting step in dolichol synthesis.

Glycobiology - 1 Oct 1993

Rosenwald A G, Stanley P, McLachlan K R, Krag S S

Abstract excerpt

Chinese hamster ovary (CHO) cells of the Lec9 recessive complementation group display a distinctive profile of resistance to a variety of toxic lectins. In addition, they accumulate cis-alpha-unsaturated polyprenol and use mainly polyprenol rather than dolichol to synthesize the glycosylated lipi...

Topics

Animals
CHO Cells
Cricetinae
Dolichols
Drug Resistance
Genetic Complementation Test
Hybrid Cells
Kinetics
Lectins
Lipid Metabolism
Mutation
Phenotype
Polyisoprenyl Phosphates

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