Article
Reduced utilization of Man5GlcNAc2-P-P-lipid in a Lec9 mutant of Chinese hamster ovary cells: analysis of the steps in oligosaccharide-lipid assembly.
Journal of cellular biochemistry - 1 Nov 1997
Hall C W, McLachlan K R, Krag S S, Robbins A R
Abstract excerpt
Recently we reported that CHB11-1-3, a Chinese hamster ovary cell mutant defective in glycosylation of asparagine-linked proteins, is defective in the synthesis of dolichol [Quellhorst et al., 343:19-26, 1997: Arch Biochem Biophys]. CHB11-1-3 was found to be in the Lec9 complementation group, whi...
Topics
- Animals
- Biological Transport
- CHO Cells
- Carbohydrate Sequence
- Cell Membrane
- Cricetinae
- Dolichols
- Electrophoresis, Polyacrylamide Gel
- GTP-Binding Proteins
- Glycosylation
- Hemiterpenes
- Lipid Metabolism
- Mannose
- Methionine
- Molecular Sequence Data
- Mutation
- Pentanols
- Polyisoprenyl Phosphate Sugars