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The N-glycosylation defect in Lec5 and Lec9 CHO cells is caused by absence of the DHRSX gene

2024-06-18

Abstract excerpt

Glycosylation-deficient Chinese hamster ovary (CHO) cell lines have been instrumental in the discovery of N-glycosylation machinery. Yet, the molecular causes of the glycosylation defects in the Lec5 and Lec9 mutants have been elusive, even though for both cell lines a defect in dolichol formation from polyprenol was previously established. We recently found that dolichol synthesis from polyprenol occurs in three...

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Literature Corpus work: f4743dcc-9c9d-5e87-98bb-843632f4ea70
DOI: 10.1101/2024.06.18.599300

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