Article
The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.
Immunological reviews - 1 Apr 1998
Manser T, Tumas-Brundage K M, Casson L P, Giusti A M, Hande S, Notidis E, Vora K A
Abstract excerpt
Somatic hypermutation and selection of immunoglobulin (Ig) variable (V)-region genes, working in concert, appear to be essential for memory B-cell development in mammals. There has been substantial progress on the nature of the cis-acting DNA elements that regulate hypermutation. The data obtained suggest that the mechanisms of Ig gene hypermutation and transcription are intimately intertwined. While it has long...
Topics
- Animals
- Antibody Diversity
- B-Lymphocytes
- Dendritic Cells
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunologic Memory
- Mutation
- Selection, Genetic