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Article

The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.

Immunological reviews - 1 Apr 1998

Manser T, Tumas-Brundage K M, Casson L P, Giusti A M, Hande S, Notidis E, Vora K A

Abstract excerpt

Somatic hypermutation and selection of immunoglobulin (Ig) variable (V)-region genes, working in concert, appear to be essential for memory B-cell development in mammals. There has been substantial progress on the nature of the cis-acting DNA elements that regulate hypermutation. The data obtained suggest that the mechanisms of Ig gene hypermutation and transcription are intimately intertwined. While it has long...

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Identifiers

PMID: 9602364
DOI: 10.1111/j.1600-065x.1998.tb01441.x

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