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Article

B cell receptor editing in tolerance and autoimmunity

1 Jan 2011

Abstract excerpt

Receptor editing is the process of ongoing antibody gene rearrangement in a lymphocyte that already has a functional antigen receptor. The expression of a functional antigen receptor will normally terminate further rearrangement (allelic exclusion). However, lymphocytes with autoreactive receptors have a chance at escaping negative regulation by "editing" the specificities of their receptors with additional...

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Identifiers

PMID: 21251012
DOI: 10.1111/j.1749-6632.2010.05877.x

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