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Article

A large kindred with 17q-linked breast and ovarian cancer: genetic, phenotypic, and genealogical analysis.

Journal of the National Cancer Institute - 2 Feb 1994

Goldgar D E, Fields P, Lewis C M, Tran T D, Cannon-Albright L A, Ward J H, Swensen J, Skolnick M H

Abstract excerpt

BACKGROUND: Mutation of a specific, but as yet unidentified, gene BRCA1 on chromosome 17q results in increased susceptibility to breast and ovarian cancer. It is important to know the effects of this gene in terms of the age-specific risks of these cancers and the potential interaction of this gene with other known risk factors. PURPOSE: We performed detailed studies on a large multigenerational family, in which...

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Identifiers

PMID: 8283492
DOI: 10.1093/jnci/86.3.200

Genes

BRCA1

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