Article
A large kindred with 17q-linked breast and ovarian cancer: genetic, phenotypic, and genealogical analysis.
Journal of the National Cancer Institute - 2 Feb 1994
Goldgar D E, Fields P, Lewis C M, Tran T D, Cannon-Albright L A, Ward J H, Swensen J, Skolnick M H
Abstract excerpt
BACKGROUND: Mutation of a specific, but as yet unidentified, gene BRCA1 on chromosome 17q results in increased susceptibility to breast and ovarian cancer. It is important to know the effects of this gene in terms of the age-specific risks of these cancers and the potential interaction of this ge...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- Female
- Genetic Linkage
- Genotype
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Ovarian Neoplasms
- Pedigree
- Phenotype