Article
Loss of heterozygosity on chromosome arm 16q in breast cancer metastases.
Genes, chromosomes & cancer - 1 Jul 1997
Driouch K, Dorion-Bonnet F, Briffod M, Champéme M H, Longy M, Lidereau R
Abstract excerpt
One of the main genetic abnormalities associated with breast carcinogenesis is the loss of genetic material from chromosome arm 16q. Different groups have identified two regions (16q22.1 and 16q24-ter) that are frequently deleted in primary tumors, suggesting the presence of tumor suppressor genes in these regions. Little is known about the late stages of tumor progression in this respect, and we, therefore,...
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