Article
High frequency of allelic imbalance at chromosome region 16q22-23 in human breast cancer: correlation with high PgR and low S phase.
International journal of cancer - 21 Apr 1995
Skirnisdottir S, Eiriksdottir G, Baldursson T, Barkardottir R B, Egilsson V, Ingvarrson S
Abstract excerpt
The loss of genetic material from a specific chromosome region in tumors suggests that presence of tumor-suppressor genes. Loss of heterozygosity (LOH) or allelic imbalance (AI) on the long arm of chromosome 16 is a known event in sporadic breast cancer. To locate the commonly deleted regions, an...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 16
- DNA, Neoplasm
- Heterozygote
- Humans
- Middle Aged
- Molecular Sequence Data
- Multivariate Analysis
- Polymerase Chain Reaction
- Proportional Hazards Models
- Receptors, Progesterone
- S Phase
- Survival Analysis