Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progression as exemplified by human astrocytic tumors.

Seminars in cancer biology - 1 Aug 1999

Collins V P

Abstract excerpt

The last 10 years has seen major improvements in our understanding of the genetic anomalies that lie behind the development and progression of human astrocytic tumors. The least aggressive astrocytomas frequently show loss of wild type p53 as well as losses of alleles from a number of regions of the genome. The genes targeted have yet to be identified. The most aggressive tumors, the glioblastomas, show mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Progression

Share to Glioblastoma

Share to Mutation

Share to Oncogenes

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 10448114
DOI: 10.1006/scbi.1999.0132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progression as exemplified by human astrocytic tumors.PMID 10448114Read ↗

A Molecular Genetic Model of Astrocytoma HistopathologySemantic proximity Read ↗

Genetic and epigenetic contribution to astrocytic gliomas pathogenesisSemantic proximity Read ↗

Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression.Semantic proximity Read ↗

Molecular pathogenesis of astrocytic tumours.Semantic proximity Read ↗

Genetic alterations associated with glioma progression.Semantic proximity Read ↗

Genetic alterations associated with the evolution and progression of astrocytic brain tumours.Semantic proximity Read ↗

Gliomas.Semantic proximity Read ↗

Early genetic changes involved in low-grade astrocytic tumor development.Semantic proximity Read ↗

Pattern of mutant p53 expression in human astrocytomas suggests the existence of alternate pathways of tumorigenesis.Semantic proximity Read ↗

Signaling Pathways Regulating GliomagenesisSemantic proximity Read ↗

Accumulation of genetic defects during astrocytoma progression.Semantic proximity Read ↗

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.