Article
Slowed receptor trafficking in mutant CHO lines of the End1 and End2 complementation groups.
Journal of cellular physiology - 1 Jan 1994
Johnson L S, Presley J F, Park J C, McGraw T E
Abstract excerpt
A mutant Chinese hamster ovary cell line with nonconditional kinetic defects in receptor internalization and recycling was isolated, based on selection for resistance to a transferrin-diphtheria toxin conjugate and screening for aberrant receptor trafficking. The 12-4 cell line internalizes trans...
Topics
- Animals
- CHO Cells
- Cricetinae
- Endocytosis
- Genetic Complementation Test
- Lipoproteins, LDL
- Mutation
- Phenotype
- Receptors, Cell Surface
- Receptors, Lipoprotein
- Receptors, Transferrin
- Time Factors
- Transferrin