Article
The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected.
The Journal of cell biology - 1 Sept 1993
Presley J F, Mayor S, Dunn K W, Johnson L S, McGraw T E, Maxfield F R
Abstract excerpt
We have characterized a new CHO cell line (12-4) derived from a parental line, TRVb-1, that expresses the human transferrin receptor. This mutant belongs to the end2 complementation group of endocytosis mutants. Like other end2 mutants, the endosomes in 12-4 cells show a partial acidification def...
Topics
- 4-Chloro-7-nitrobenzofurazan
- Animals
- Biological Transport
- CHO Cells
- Cell Compartmentation
- Cell Membrane
- Cricetinae
- Endocytosis
- Fluorescein-5-isothiocyanate
- Fluorescent Dyes
- Hydrogen-Ion Concentration
- Image Processing, Computer-Assisted
- Intracellular Membranes