Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected.

The Journal of cell biology - 1 Sept 1993

Presley J F, Mayor S, Dunn K W, Johnson L S, McGraw T E, Maxfield F R

Abstract excerpt

We have characterized a new CHO cell line (12-4) derived from a parental line, TRVb-1, that expresses the human transferrin receptor. This mutant belongs to the end2 complementation group of endocytosis mutants. Like other end2 mutants, the endosomes in 12-4 cells show a partial acidification defect. These cells internalize LDL and transferrin at 70% of the rate of parental cells and externalize transferrin at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cell Compartmentation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Membrane

Share to CHO Cells

Share to Cricetinae

Share to Hydrogen-Ion Concentration

Share to Microscopy, Fluorescence

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 8376460
DOI: 10.1083/jcb.122.6.1231
PMCID: PMC2119853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected.PMID 8376460Read ↗

Slowed receptor trafficking in mutant CHO lines of the End1 and End2 complementation groups.Semantic proximity Read ↗

The receptor-recycling and lysosome biogenesis mutant TfT1.11 belongs to a new complementation group, End6.Semantic proximity Read ↗

The Endosomal Recycling Pathway—At the Crossroads of the CellSemantic proximity Read ↗

Rapid transbilayer movement of fluorescent phospholipid analogues in the plasma membrane of endocytosis-deficient yeast cells does not require the Drs2 protein.Semantic proximity Read ↗

A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis.Semantic proximity Read ↗

Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice.Semantic proximity Read ↗

Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.Semantic proximity Read ↗

Impaired secretion and fluid-phase endocytosis in the End4 mutant of Chinese hamster ovary cells.Semantic proximity Read ↗

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.Semantic proximity Read ↗

Recovery of function in Chinese hamster ovary cell mutants with temperature-sensitive defects in vacuolar acidification.Semantic proximity Read ↗

Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells.Semantic proximity Read ↗

Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.