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Article

Biosynthesis of lysosomal enzymes in cells of the End3 complementation group conditionally defective in endosomal acidification.

Somatic cell and molecular genetics - 1 Mar 1991

Park J E, Draper R K, Brown W J

Abstract excerpt

Various aspects of lysosome biogenesis have been studied in Chinese hamster ovary (CHO) cells of the End3 complementation group (designated G.7.1 cells), which display a temperature-sensitive defect in the acidification of endosomes, but not lysosomes. In G.7.1 and normal wild-type cells grown at the permissive temperature (34 degrees C), the lysosomal enzymes alpha-glucosidase and cathepsin D were synthesized as...

Topics

Animals
Cathepsin D
Cell Line
Cricetinae
Cricetulus
Electrophoresis, Polyacrylamide Gel
Glucan 1,4-alpha-Glucosidase
Hydrogen-Ion Concentration
Lysosomes
Mannosephosphates
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein Processing, Post-Translational

Receptor, IGF Type 2

Receptors, Cell Surface

Source

Identifiers

PMID: 1849319
DOI: 10.1007/BF01232971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1849319-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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