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Article

Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP.

The Journal of cell biology - 1 Jun 1994

Guo Q, Vasile E, Krieger M

Abstract excerpt

The CHO cell temperature-sensitive mutant ldlF exhibits two defects in membrane traffic at the nonpermissive temperature (39.5 degrees C): rapid degradation of LDL receptors, possibly caused by endocytic missorting, and disruption of ER-through-Golgi transport. Here, we show that at 39.5 degrees C, the Golgi in ldlF cells dissociated into vesicles and tubules. This dissociation was inhibited by AlF4-, suggesting...

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Identifiers

PMID: 8207054
DOI: 10.1083/jcb.125.6.1213
PMCID: PMC2290926

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