Article
Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP.
The Journal of cell biology - 1 Jun 1994
Guo Q, Vasile E, Krieger M
Abstract excerpt
The CHO cell temperature-sensitive mutant ldlF exhibits two defects in membrane traffic at the nonpermissive temperature (39.5 degrees C): rapid degradation of LDL receptors, possibly caused by endocytic missorting, and disruption of ER-through-Golgi transport. Here, we show that at 39.5 degrees...
Topics
- Aluminum Compounds
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- CHO Cells
- Cloning, Molecular
- Coatomer Protein
- Cricetinae
- DNA, Complementary
- Endocytosis
- Fluorides
- Genes, Lethal
- Golgi Apparatus
- Hot Temperature
- Intracellular Membranes
- Membrane Proteins
- Molecular Sequence Data