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Article

Amplification of Epidermal Growth Factor Receptor Gene in Gliomas: Histopathology and Prognosis

1 Jan 1992

Abstract excerpt

In order to evaluate the incidence and prognostic significance of gene amplification in primary brain neoplasms we measured the number of gene copies per cell of three oncogenes (epidermal growth factor receptor [EGFR] gene, N-myc, C-myc) and syntenic control genes in 40 specimens using quantitative DNA dot blots. We observed EGFR gene amplification in astrocytomas and anaplastic astrocytomas with approximately...

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Identifiers

PMID: 1311022
DOI: 10.1097/00005072-199201000-00010

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Source receipt: pubmed, retrieved 7 Sept 2026.

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