A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

doi:10.1073/pnas.91.16.7727

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Article

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 1994

Nishikawa R, Ji X D, Harmon R C, Lazar C S, Gill G N, Cavenee W K, Huang H J

Abstract excerpt

The development and neoplastic progression of human astrocytic tumors appears to result through an accumulation of genetic alterations occurring in a relatively defined order. One such alteration is amplification of the epidermal growth factor receptor (EGFR) gene. This episomal amplification occurs in 40-50% of glioblastomas, which also normally express endogenous receptors. Moreover, a significant fraction of...

Topics

Animals
Base Sequence
Brain
Cell Transformation, Neoplastic
ErbB Receptors
Exons
Female
Glioblastoma
Humans
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Molecular Sequence Data

Mutation

Neoplasms, Experimental

Phosphorylation

Recombinant Proteins

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8052651
DOI: 10.1073/pnas.91.16.7727
PMCID: PMC44475

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8052651-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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