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Article

New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profile.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2010

Lopez-Gines Concha, Gil-Benso Rosario, Ferrer-Luna Ruben, Benito Rafael, Serna Eva, Gonzalez-Darder Jose, Quilis Vicente, Monleon Daniel, Celda Bernardo, Cerdá-Nicolas Miguel

Abstract excerpt

Gene amplification is a process that is characterized by an increase in the copy number of a restricted region in a chromosome arm, and is frequently associated with an overexpression of the corresponding amplified gene. Amplified DNA can be organized either as extrachromosomal elements, repeated units at a single locus or scattered throughout the genome. The amplification of the gene for epidermal growth factor...

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Source

Identifiers

PMID: 20305620
DOI: 10.1038/modpathol.2010.62

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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