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Article

DUN1 encodes a protein kinase that controls the DNA damage response in yeast.

Cell - 17 Dec 1993

Zhou Z, Elledge S J

Abstract excerpt

DNA damage induces the expression of many genes proposed to enhance DNA repair capacities. We investigated the mechanism by which DNA damage induces transcription of RNR3, a subunit of ribonucleotide reductase. Five complementation groups of DNA-damage uninducible (dun) mutants were identified. Each is sensitive to DNA damage. dun1 mutants are also defective for RNR1 and RNR2 induction but are proficient for...

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PMID: 8261511
DOI: 10.1016/0092-8674(93)90321-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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DUN1 encodes a protein kinase that controls the DNA damage response in yeast.PMID 8261511Read ↗

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.Semantic proximity Read ↗

DNA damage and cell cycle regulation of ribonucleotide reductase.Semantic proximity Read ↗

Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase.Semantic proximity Read ↗

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.Semantic proximity Read ↗

Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.Semantic proximity Read ↗

Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.Semantic proximity Read ↗

Budding yeast CTDK-I is required for DNA damage-induced transcription.Semantic proximity Read ↗

Radiosensitive and mitotic recombination phenotypes of the Saccharomyces cerevisiae dun1 mutant defective in DNA damage-inducible gene expression.Semantic proximity Read ↗

DNA-damage induction of RAD54 can be regulated independently of the RAD9- and DDC1-dependent checkpoints that regulate RNR2.Semantic proximity Read ↗

Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of a novel DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, which is a structural homolog of the RAD2 and RAD27 DNA repair genes.Semantic proximity Read ↗

Yap1: a DNA damage responder in Saccharomyces cerevisiae.Semantic proximity Read ↗

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