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Article

Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.

PLoS genetics - 1 May 2011

Tsaponina Olga, Barsoum Emad, Aström Stefan U, Chabes Andrei

Abstract excerpt

The Saccharomyces cerevisiae Dun1 protein kinase is a downstream target of the conserved Mec1-Rad53 checkpoint pathway. Dun1 regulates dNTP pools during an unperturbed cell cycle and after DNA damage by modulating the activity of ribonucleotide reductase (RNR) by multiple mechanisms, including phosphorylation of RNR inhibitors Sml1 and Dif1. Dun1 also activates DNA-damage-inducible genes by inhibiting the Crt1...

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PMID: 21573136
DOI: 10.1371/journal.pgen.1002061
PMCID: PMC3088718

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Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.PMID 21573136Read ↗

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.Semantic proximity Read ↗

Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.Semantic proximity Read ↗

DNA-damage induction of RAD54 can be regulated independently of the RAD9- and DDC1-dependent checkpoints that regulate RNR2.Semantic proximity Read ↗

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage.Semantic proximity Read ↗

DUN1 encodes a protein kinase that controls the DNA damage response in yeast.Semantic proximity Read ↗

Two alternative cell cycle checkpoint pathways differentially control DNA damage-dependent induction of MAG1 and DDI1 expression in yeast.Semantic proximity Read ↗

Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase.Semantic proximity Read ↗

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.Semantic proximity Read ↗

Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.Semantic proximity Read ↗

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.Semantic proximity Read ↗

Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase.Semantic proximity Read ↗

Tolerance to replication stress requires Dun1p kinase and activation of the electron transport chain.Semantic proximity Read ↗

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