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Article

Budding yeast CTDK-I is required for DNA damage-induced transcription.

Eukaryotic cell - 1 Apr 2003

Ostapenko Denis, Solomon Mark J

Abstract excerpt

CTDK-I phosphorylates the C-terminal domain (CTD) of the large subunit of yeast RNA polymerase II in a reaction that stimulates transcription elongation. Mutations in CTDK-I subunits-Ctk1p, Ctk2p, and Ctk3p-confer conditional phenotypes. In this study, we examined the role of CTDK-I in the DNA damage response. We found that mutation of individual CTDK-I subunits rendered yeast sensitive to hydroxyurea (HU) and UV...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12684377
DOI: 10.1128/EC.2.2.274-283.2003
PMCID: PMC154854

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Source receipt: pubmed, retrieved 7 Sept 2026.

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