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Article

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Zhao Xiaolan, Rothstein Rodney

Abstract excerpt

Cell cycle checkpoints are evolutionarily conserved surveillance systems that protect genomic stability and prevent oncogenesis in mammals. One important target of checkpoint control is ribonucleotide reductase (RNR), which catalyzes the rate-limiting step in dNTP and DNA synthesis. In both yeast and humans, RNR is transcriptionally induced after DNA damage via Mec1/Rad53 (yeast) and ATM/CHK2 (human) checkpoint...

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Identifiers

PMID: 11904430
DOI: 10.1073/pnas.062502299
PMCID: PMC122595

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.PMID 11904430Read ↗

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage.Semantic proximity Read ↗

Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.Semantic proximity Read ↗

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.Semantic proximity Read ↗

Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.Semantic proximity Read ↗

Tolerance to replication stress requires Dun1p kinase and activation of the electron transport chain.Semantic proximity Read ↗

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.Semantic proximity Read ↗

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.Semantic proximity Read ↗

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.Semantic proximity Read ↗

DUN1 encodes a protein kinase that controls the DNA damage response in yeast.Semantic proximity Read ↗

Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.Semantic proximity Read ↗

Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA damage and cell cycle regulation of ribonucleotide reductase.Semantic proximity Read ↗

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