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Article

Inheritance of susceptibility to induction of nephroblastomas in the Noble rat.

Differentiation; research in biological diversity - 1 Apr 2009

Diwan Bhalchandra A, Timofeeva Olga, Rice Jerry M, Yang Yili, Sharma Nirmala, Fortini Mark E, Wang Honghe, Perantoni Alan O

Abstract excerpt

Noble (Nb) strain rats are susceptible to nephroblastoma induction with transplacental exposure to direct-acting alkylating agent N-nitrosoethylurea (ENU), while F344 strain rats are highly resistant. To study the inheritance of susceptibility to induction of these embryonal renal tumors, fetal Nb and F344 rats and F1, F2 and reciprocal backcross hybrids were exposed transplacentally to ENU once on day 18 of...

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Identifiers

PMID: 19281789
DOI: 10.1016/j.diff.2008.12.003
PMCID: PMC2696123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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