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Article

How sensitive is PCR-SSCP?

1 Jan 1993

Abstract excerpt

Single-strand conformation polymorphism analysis (SSCP) is a rapid method for detection of minor sequence changes in polymerase chain reaction-amplified DNA. Since the first reported use of SSCP in 1989 (Orita et al., 1989), this technique has been used widely to detect mutations in oncogenes, tumor suppressor genes, and genes responsible for genetic diseases. Published mutations that have been detected using...

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PMID: 8257985
DOI: 10.1002/humu.1380020503

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