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Article

The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions.

Genomics - 1 May 1993

Sheffield V C, Beck J S, Kwitek A E, Sandstrom D W, Stone E M

Abstract excerpt

Single-strand conformation polymorphism (SSCP) analysis has proven to be a simple and effective technique for the detection of single base substitutions. We have used SSCP to analyze 29 mouse globin mutations, 27 p53 mutations, and 8 rhodopsin mutations contained within different size PCR products. Our results indicate that the type of mutation (transition versus transversion) did not play a major role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8314571
DOI: 10.1006/geno.1993.1193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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