William L. McGuire Memorial Symposium. The role and prognostic significance of p53 gene alterations in breast cancer.

doi:10.1007/BF00683196

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Article

William L. McGuire Memorial Symposium. The role and prognostic significance of p53 gene alterations in breast cancer.

Breast cancer research and treatment - 1 Jan 1993

Elledge R M, Fuqua S A, Clark G M, Pujol P, Allred D C

Abstract excerpt

Alterations in the p53 tumor suppressor gene are the most frequent genetic changes found in breast cancer, with an incidence reported in a range of 15 to 50%. The incidence of p53 alterations is approximately 15% for in situ carcinoma, while for invasive node-positive disease it is 2 to 3 times h...

Topics

Amino Acid Sequence
Base Sequence
Breast Neoplasms
Carcinoma in Situ
Chromosomes, Human, Pair 17
Female
Frameshift Mutation
Genes, p53
Humans
Mutation
Point Mutation
Prognosis
Sequence Deletion
Survival Rate

Source

Open in PubMed

Identifiers

PMID: 8260732
DOI: 10.1007/BF00683196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8260732-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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