Article
William L. McGuire Memorial Symposium. The role and prognostic significance of p53 gene alterations in breast cancer.
Breast cancer research and treatment - 1 Jan 1993
Elledge R M, Fuqua S A, Clark G M, Pujol P, Allred D C
Abstract excerpt
Alterations in the p53 tumor suppressor gene are the most frequent genetic changes found in breast cancer, with an incidence reported in a range of 15 to 50%. The incidence of p53 alterations is approximately 15% for in situ carcinoma, while for invasive node-positive disease it is 2 to 3 times higher. This high rate of alteration suggests that the gene plays a central role in the development of breast cancer....
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