Article
A prospective study of the significance of gene and chromosome alterations as prognostic indicators of breast cancer patients with lymph node metastases.
Breast cancer research and treatment - 1 Mar 1998
Tsuda H, Sakamaki C, Tsugane S, Fukutomi T, Hirohashi S
Abstract excerpt
In 150 surgically resected primary breast carcinomas that had axillary lymph-node metastases, we examined the incidence of loss of heterozygosity on chromosomes 16p, 16q, 17p, 17q, and 18q, point mutation of the p53 tumor-suppressor gene, nuclear immunoreaction of p53 protein, and amplifications...
Topics
- Adult
- Aged
- Biomarkers, Tumor
- Breast Neoplasms
- Carcinoma
- Chromosome Aberrations
- Female
- Fibroblast Growth Factor 3
- Fibroblast Growth Factors
- Genes, erbB-2
- Genes, p53
- Humans
- Lymphatic Metastasis
- Middle Aged
- Mutation
- Prognosis
- Prospective Studies
- Proto-Oncogene Proteins