Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons.

Article

Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons.

JAMA - 12 Mar 1997

Evans D A, Beckett L A, Field T S, Feng L, Albert M S, Bennett D A, Tycko B, Mayeux R

Abstract excerpt

OBJECTIVE: To examine the relation between apolipoprotein E status and risk of Alzheimer disease (AD) in a defined population and estimate the fraction of incident AD attributable to the epsilon4 allele. DESIGN: Community-based cohort study. SETTING: East Boston, Mass. PARTICIPANTS: A random samp...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Cohort Studies
Female
Gene Frequency
Genotype
Humans
Incidence
Logistic Models
Male
Multivariate Analysis
Risk Factors

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