Article
Alterations of a Zinc Finger-Encoding Gene, <i>BCL-6</i> , in Diffuse Large-Cell Lymphoma
29 Oct 1993
Abstract excerpt
The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of...
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