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Article

Identification of genetic lesions associated with diffuse large-cell lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 1994

Dalla-Favera R, Ye B H, Lo Coco F, Gaidano G, Lista F, Knowles D M, Louie D C, Offit K, Chaganti R S

Abstract excerpt

BACKGROUND: The pathogenesis of several subtypes of non-Hodgkin's lymphoma (NHL) is associated with specific genetic lesions involving oncogenes and tumor-suppressor genes. These lesions include c-myc translocation and p53 inactivation in small noncleaved-cell lymphoma, and bcl-2 and bcl-1 translocation in follicular (FL) and mantle-zone lymphoma, respectively. Relatively little is known, however, about the...

Topics

Humans
Lymphoma, Large B-Cell, Diffuse
Mutation
Proto-Oncogene Mas
Proto-Oncogenes
Transformation, Genetic
Translocation, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8172819
DOI: 10.1093/annonc/5.suppl_1.s55

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8172819-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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