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Article

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

The EMBO journal - 15 Dec 1995

Ye B H, Chaganti S, Chang C C, Niu H, Corradini P, Chaganti R S, Dalla-Favera R

Abstract excerpt

The BCL6 gene codes for a zinc-finger transcription factor and is involved in chromosomal rearrangements in 30-40% of diffuse large-cell lymphoma (DLCL). These rearrangements cluster within the 5' regulatory region of BCL6 spanning its first non-coding exon. To determine the functional consequences of these alterations, we have analyzed the structure of the rearranged BCL6 alleles and their corresponding RNA and...

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Topics

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Share to Alleles
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA, Complementary

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Share to Molecular Sequence Data

Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 8557040
DOI: 10.1002/j.1460-2075.1995.tb00311.x
PMCID: PMC394745

Genes

BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.PMID 8557040Read ↗

The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene.Semantic proximity Read ↗

The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene.Semantic proximity Read ↗

Pathogenetic and Clinical Implications of Non-Immunoglobulin; BCL6 Translocations in B-Cell Non-Hodgkin's LymphomaSemantic proximity Read ↗

Alterations of a Zinc Finger-Encoding Gene, <i>BCL-6</i> , in Diffuse Large-Cell LymphomaSemantic proximity Read ↗

Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphomaSemantic proximity Read ↗

The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphomaSemantic proximity Read ↗

The human <i>BCL6</i> transgene promotes the development of lymphomas in the mouseSemantic proximity Read ↗

The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.Semantic proximity Read ↗

BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphomaSemantic proximity Read ↗

Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6.Semantic proximity Read ↗

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.Semantic proximity Read ↗

BCL-6: rearrangement and mutation in lymphoma.Semantic proximity Read ↗

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