Article
BCL-6 in aids-related lymphomas: pathogenetic and histogenetic implications.
Leukemia & lymphoma - 1 Sept 1998
Gaidano G, Capello D, Gloghini A, Pastore C, Migliazza A, Quattrone S, Savinelli F, Buonaiuto D, Cilia A M, Perin T, Pasqualucci L, Canzonieri V, Saglio G, Dalla-Favera R, Carbone A
Abstract excerpt
AIDS-related non-Hodgkin's lymphomas (AIDS-NHL) are classified into Burkitt's lymphoma, diffuse large cell lymphoma (DLCL), and body cavity based lymphoma. The molecular pathogenesis of AIDS-NHL is complex and involves the genetic alteration of several cancer related genes, including the BCL-6 proto-oncogene. BCL-6 encodes a zinc finger transcription factor which is selectively expressed by germinal center (GC)...
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