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Article

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 1995

Migliazza A, Martinotti S, Chen W, Fusco C, Ye B H, Knowles D M, Offit K, Chaganti R S, Dalla-Favera R

Abstract excerpt

The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal arrangements in its 5' noncoding region in approximately 30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types...

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Source

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Identifiers

PMID: 8618933
DOI: 10.1073/pnas.92.26.12520
PMCID: PMC40389

Genes

BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8618933-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.PMID 8618933Read ↗

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Analysis of hypermutation of the 5' noncoding region in the BCL-6 gene.Semantic proximity Read ↗

Alterations of a Zinc Finger-Encoding Gene, <i>BCL-6</i> , in Diffuse Large-Cell LymphomaSemantic proximity Read ↗

Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia.Semantic proximity Read ↗

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.Semantic proximity Read ↗

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