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Article

Molecular Pathogenesis of Non-Hodgkin's Lymphoma: the Role of Bcl-6

1 Nov 2003

Abstract excerpt

Non-Hodgkin's lymphomas (NHL) form a heterogeneous group of diseases, with diffuse large B-cell lymphoma (DLBCL) comprising the largest subgroup. The commonest chromosomal translocations found in DLBCL are those affecting band 3q27. In 35% of DLBCL cases, as well as in a small fraction of follicular lymphomas, the normal transcriptional regulation of Bcl-6 is disrupted by these chromosomal translocations. In...

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PMID: 15202519
DOI: 10.1080/10428190310001621588

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