Article
BCL-6: rearrangement and mutation in lymphoma.
Methods in molecular medicine - 1 Jan 2005
Wagner Simon D, Kaeda Jaspal S
Abstract excerpt
BCL-6 is a zinc finger transcription factor that is highly expressed in normal germinal center B-cells. Its function is to prevent differentiation and apoptosis and allow growth. BCL-6 also is expressed in various lymphoproliferative conditions, for example, diffuse large cell lymphoma, Burkitt's lymphoma, and follicular lymphoma as well as lymphocyte predominant Hodgkin's disease. Expression also has been...
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