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BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma

26 Oct 2005

Abstract excerpt

The BCL6 transcriptional repressor mediates survival, proliferation, and differentiation blockade of B cells during the germinal-center reaction and is frequently misregulated in B-cell non-Hodgkin lymphoma (BNHL). The p53 tumor-suppressor gene is central to tumorigenesis. Microarray analysis identified BCL6 as a primary target of p53. The BCL6 intron 1 contains a region in which 3 types of genetic alterations...

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PMID: 16249378
DOI: 10.1182/blood-2005-04-1629

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