Article
The proto-oncogene BCL-6 in normal and malignant B cell development.
Hematological oncology - 1 Dec 2002
Niu Huifeng
Abstract excerpt
BCL-6 is an important regulator of the immune system. It is required for GC formation and T cell dependent antibody responses. Mice deficient in BCL-6 fail to form GC and mount reduced levels of T cell-dependent antibody responses. BCL-6 (-/-) mice, in addition, develop a massive inflammatory res...
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