Article
Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells.
The Journal of investigative dermatology - 1 Nov 1993
Waters H L, Seetharam S, Seidman M M, Kraemer K H
Abstract excerpt
Patients with the variant form of xeroderma pigmentosum (XP) have clinical XP including a high frequency of skin cancer but, in contrast to the other forms of XP, have normal post-ultraviolet (UV) DNA excision repair and nearly normal post-UV survival. However, like excision repair-deficient XP cells, the XP variant cells are UV hypermutable. We used a UV-treated plasmid shuttle vector, pZ189, to examine the DNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.