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Article

A potential laboratory test for dysplastic nevus syndrome: ultraviolet hypermutability of a shuttle vector plasmid.

The Journal of investigative dermatology - 1 Jul 1994

Moriwaki S, Tarone R E, Kraemer K H

Abstract excerpt

The diagnosis of the melanoma-prone disorder dysplastic nevus syndrome (DNS) is based currently on a combination of clinical and histopathologic examinations of patients. To develop a potential laboratory test for DNS, we utilized the observation that an ultraviolet light (UV)-treated mutagenesis plasmid shuttle vector has an abnormally increased frequency of mutations after transfection into lymphoblastoid cells...

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Identifiers

PMID: 8027583
DOI: 10.1111/1523-1747.ep12388847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A potential laboratory test for dysplastic nevus syndrome: ultraviolet hypermutability of a shuttle vector plasmid.PMID 8027583Read ↗

Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells.Semantic proximity Read ↗

Ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum lymphoblastoid cells and fibroblasts.Semantic proximity Read ↗

Analysis of N-methyl-N-nitrosourea-induced mutations in a shuttle vector plasmid propagated in mouse O6-methylguanine-DNA methyltransferase-deficient cells in comparison with proficient cells.Semantic proximity Read ↗

A signature element distinguishes sibling and independent mutations in a shuttle vector plasmid.Semantic proximity Read ↗

Analysis of point mutations in an ultraviolet-irradiated shuttle vector plasmid propagated in cells from Japanese xeroderma pigmentosum patients in complementation groups A and F.Semantic proximity Read ↗

Sequence-dependent mutations in a shuttle vector plasmid replicated in a mismatch repair deficient human cell line.Semantic proximity Read ↗

Similarity in the molecular profile of mutations induced by UV light in shuttle vector plasmids propagated in mouse and human cells.Semantic proximity Read ↗

Ultraviolet mutagenesis in human lymphocytes: the effect of cellular transformation.Semantic proximity Read ↗

Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells.Semantic proximity Read ↗

Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189.Semantic proximity Read ↗

Comparing the frequency and spectra of mutations induced when an SV-40 based shuttle vector containing covalently bound residues of structurally-related carcinogens replicates in human cells.Semantic proximity Read ↗

Mutational hotspot variability in an ultraviolet-treated shuttle vector plasmid propagated in xeroderma pigmentosum and normal human lymphoblasts and fibroblasts.Semantic proximity Read ↗

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