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Article

Ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum lymphoblastoid cells and fibroblasts.

Mutation research - 1 Jan 1991

Seetharam S, Kraemer K H, Waters H L, Seidman M M

Abstract excerpt

In order to examine possible cell-type specificity in mutagenic events, a shuttle-vector plasmid, pZ189, carrying a bacterial suppressor tRNA marker gene, was treated with ultraviolet radiation and propagated in Epstein-Barr virus transformed lymphoblastoid cell lines from a patient, XP12BE, with xeroderma pigmentosum (XP), group A, and a normal control. XP is a skin-cancer-prone disorder with UV hypersensitivity...

Topics

Base Sequence
Cell Line
DNA Mutational Analysis
DNA Repair
Escherichia coli
Fibroblasts
Genes, Suppressor
Genetic Vectors
Humans
Lymphocytes
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plasmids

Ultraviolet Rays

Xeroderma Pigmentosum

Source

Identifiers

PMID: 1986277
DOI: 10.1016/0921-8777(91)90045-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1986277-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum lymphoblastoid cells and fibroblasts.PMID 1986277Read ↗

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