Mutational hotspot variability in an ultraviolet-treated shuttle vector plasmid propagated in xeroderma pigmentosum and normal human lymphoblasts and fibroblasts.

doi:10.1016/0022-2836(90)90319-H

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Article

Mutational hotspot variability in an ultraviolet-treated shuttle vector plasmid propagated in xeroderma pigmentosum and normal human lymphoblasts and fibroblasts.

Journal of molecular biology - 5 Apr 1990

Seetharam S, Kraemer K H, Waters H L, Seidman M M

Abstract excerpt

The mutagenesis shuttle vector, pZ189, was treated with ultraviolet (u.v.) radiation in vitro and passed through a DNA repair-deficient lymphoblastoid cell line derived from a patient with xeroderma pigmentosum complementation group A (XP-A) (XP12BE(EBV)) and a DNA repair-proficient lymphoblastoi...

Topics

Cell Line
DNA Repair
Fibroblasts
Humans
Lymphocytes
Mutation
Plasmids
Ultraviolet Rays
Xeroderma Pigmentosum

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