Article
Repair of DNA damage in shuttle vectors, virus, and chromosomal DNAs may depend on their biological imprinting--a 'Pygmalion' effect.
Mutation research - 1 Jan 2000
Cleaver J E, Vuksanovic L, Player A N, Lutze L H
Abstract excerpt
We have created a cell line that can repair damage in chromosomal DNA and in herpes virus, while not repairing the same damage in shuttle vectors (pZ189 and pRSVcat). This cell line, a xeroderma pigmentosum (XP) revertant, repairs the minor (6-4)-photoproducts, but not cyclobutane dimers, in chro...
Topics
- Cell Line
- Chloramphenicol O-Acetyltransferase
- DNA Damage
- DNA Repair
- Gene Expression Regulation
- Genetic Vectors
- Humans
- Mutagenicity Tests
- Mutation
- Simian virus 40
- Simplexvirus
- Ultraviolet Rays
- Xeroderma Pigmentosum