Article
Mutagenicity of methyl methanesulfonate (MMS) in vivo at the Dlb-1 native locus and a lacI transgene.
Environmental and molecular mutagenesis - 1 Jan 1993
Tao K S, Urlando C, Heddle J A
Abstract excerpt
Methyl methanesulfonate (MMS) is an extraordinarily poor mutagen compared to ethylnitrosourea (ENU) or even X-rays. In lung fibroblasts in vivo, MMS has been shown to induce many micronuclei but few, if any, mutations at the hpt locus. We wondered if the lack of mutations might be due to the lack...
Topics
- Animals
- Chromogenic Compounds
- Female
- Galactosides
- Indoles
- Male
- Methyl Methanesulfonate
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutagenicity Tests
- Mutation
- Receptors, Mitogen