Article
Organ distinctive mutagenicity in MutaMouse after short-term exposure to PhIP.
Mutagenesis - 1 Sept 1996
Lynch A M, Gooderham N J, Boobis A R
Abstract excerpt
We have investigated PhIP-induced mutagenicity in various tissues (kidney, liver, large and small intestine) using a transgenic mouse model (MutaMouse). In addition to tissue specific mutagenesis, we measured the binding of [14C]PhIP to MutaMouse mice blood proteins (haemoglobin and albumin), to...
Topics
- Administration, Oral
- Animals
- Carbon Radioisotopes
- Carcinogens
- Dose-Response Relationship, Drug
- Hemoglobins
- Imidazoles
- Intestinal Mucosa
- Intestines
- Kidney
- Liver
- Male
- Mice
- Mice, Transgenic
- Models, Genetic
- Mutagenesis
- Mutagenicity Tests
- Mutagens