Article
Kinetics of induction of DNA damage and lacZ gene mutations in stomach mucosa of mice treated with beta-propiolactone and N-methyl-N'-nitro-N-nitrosoguanidine, using single-cell gel electrophoresis and MutaMouse models.
Environmental and molecular mutagenesis - 1 Jan 1999
Brault D, Renault D, Tombolan F, Thybaud V
Abstract excerpt
beta-Propiolactone (BPL) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are two direct alkylating agents that induce multiple genetic lesions and tumors in the rodent stomach. We measured the kinetics of the induction of DNA damage by using the single-cell gel electrophoresis assay (SCGE) and the induction of gene mutations by using the MutaMouse model in the glandular stomach mucosa of mice exposed to a single...
Topics
- Animals
- DNA Damage
- Electrophoresis
- Gastric Mucosa
- Kinetics
- Lac Operon
- Methylnitronitrosoguanidine
- Mice
- Mice, Transgenic
- Mutagens
- Mutation