Article
[Expression anomalies of the CD3-TCR complex expression and immunodeficiencies].
Medecine sciences : M/S - 1 Feb 2007
Le Deist Françoise, de Saint Basile Geneviève, Rieux-Laucat Frédéric, Hivroz Claire, Fischer Alain
Abstract excerpt
Molecular characterization of immunodeficiencies contributes to a better understanding of the physiological mechanisms of immune function. The T cell receptor is a heterodimer (alpha/beta or gamma/delta) associated with four transmembrane units of the CD3 complex (gamma, delta, epsilon and zeta). We herein summarize the immunodeficiency states resulting from defects in genes encoding the CD3 complex. Such...
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