Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.

doi:10.1038/362652a0

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Article

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.

Nature - 15 Apr 1993

Branch P, Aquilina G, Bignami M, Karran P

Abstract excerpt

Acquired resistance to alkylating agents such as N-methyl-N-nitrosourea or N-methyl-N'-nitro-N-nitrosoguanidine results from the ability to tolerate the potentially cytotoxic methylated base O6-methylguanine (m6-G) in DNA. In the absence of repair by demethylation in situ, m6-G is probably lethal...

Topics

Animals
Base Sequence
CHO Cells
Cricetinae
DNA Damage
DNA Repair
Drug Resistance
Guanosine
Humans
Methylation
Methylnitrosourea
Molecular Sequence Data
Mutation
Nucleic Acid Heteroduplexes
Oligodeoxyribonucleotides
Phenotype
Thymidine
Tumor Cells, Cultured

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