Article
Allele-specific DNA-protein interactions associated with the X-box regulatory region of the DQB1*0302 gene.
Autoimmunity - 1 Jan 1993
Shewey L M, Nepom G T
Abstract excerpt
The X box is an essential transcriptional regulatory region for both constitutive and inducible expression of HLA-class II genes, and, while highly conserved among class II genes, both locus- and allele-specific polymorphisms exist. Using gel regardation analysis, we have analyzed the binding of B cell nuclear proteins to the X box regions of the DQB1*0302, *0301, and DRA genes and have identified two distinct X...
Topics
- Alleles
- B-Lymphocytes
- Base Sequence
- Cell Line, Transformed
- DNA
- DNA-Binding Proteins
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Gene Expression Regulation
- Genes, MHC Class II
- Genetic Predisposition to Disease