Article
The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.
Molecular and cellular biology - 1 Sept 1992
Herrero Sanchez C, Reith W, Silacci P, Mach B
Abstract excerpt
The X box of major histocompatibility complex class II promoters is essential for proper expression of class II genes. Here we show that two distinct protein-DNA complexes (A and B), which exhibit similar binding characteristics and identical contact points on the X box, can be formed. This sugge...
Topics
- Base Sequence
- Cell Line, Transformed
- Cloning, Molecular
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes, MHC Class II
- Humans
- Leukemia, B-Cell
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Regulatory Factor X Transcription Factors